Then April Came

Osler came to Boston.

When Asperger's Disorder Came Out.

BACKGROUND In 2013, the American Psychiatric Association removed Asperger's Disorder from the DSM, offering instead the new DSM-5 diagnosis: Autism Spectrum Disorder. This change has been hailed the most controversial exclusion from the DSM, yet unlike the 1973 removal of homosexuality from DSM-III, Asperger's disorder has not been demedicalised. Rather, the disorder has simply been reclassifie...

How Human Genetics Came to Sa

S33 June 2016, Vol. 106, No. 6 (Suppl 1) The massive strides made in human genetics in the last 10 years would not have been possible without the diligent and insightful work of the pioneers in human genetics. This is particularly true in South Africa (SA), where a small community of scientists and clinicians have been responsible for the application of scientific/ medical advances into the wid...

If “it” were “then”, then when was “it”? Establishing the anaphoric role of “then”

The adverb ”then” is among the most frequent English temporal adverbs, being also capable of filling a variety of semantic roles. The identification of anaphoric usages of ”then” is important for temporal expression resolution, while the temporal relationship usage is important for event ordering. Given that previous work has not tackled the identification and temporal resolution of anaphoric ”...

Coregulators: from whence came these "master genes".

It is now over a decade since the first nuclear receptor coactivator, SRC-1, was cloned and discovered to be a new type of transcription factor that does not bind DNA, but rather, binds directly or indirectly to nuclear receptors (NRs) to mediate their transcriptional potency. The NR coactivators belong to a class of molecules now termed ‘coregulators’. Employing an ‘operational’ definition, we...